Medicinal Mushrooms: A Natural Medicine

Mushrooms have been used in folk medicine for thousands of years, particularly in the East. In fact, medicinal mushrooms were so valued in ancient Japan that one kind, the maitake, were literally worth their weight in silver. Today, their value is again being recognized. Research on medicinal mushrooms indicates various types of mushrooms have potential antiviral, antimicrobial, anticancer, anti-hyperglycemic, cardio-protective and anti-inflammatory activities.


Medicinal mushrooms are mushrooms or mushroom extracts used in the practice of medicine; especially those that contain key immunomodulating active compounds. Modern scientific studies of these mushrooms have increased significantly within the last three decades, helping to popularize these fungi and their unique health-boosting effects. That research is also working to provide explanations of how the compounds accomplish those functions in animal and human systems. Although holistic doctors have recommended these mushrooms for years, recent studies have led them to appear more and more often in peer-reviewed scientific and medical journals. That is an essential step on the road to more generalized acceptance and awareness among medical professionals. AHCC is derived from healing mushrooms, and more specifically is a standardized extract of cultured Lentinula edodes. These mushrooms are more commonly known as shiitake, and have been used in traditional medicine for centuries to treat various ailments. AHCC is anti-inflammatory, immunomodulatory, and immune system enhancing and is rich in antioxidants and alpha glucans.


It might seem, based on their benefits, that everyone should add medicinal mushrooms as a staple to their diet.

The problem with that logic, however, is that in their natural form are poorly absorbed: their biologically active component (polysaccharides) are too large to slip through the small openings in the stomach and intestine meant to absorb nutrients.

However a group of scientists in Tokyo solved this problem in 1987 with the creation of AHCC, a natural immune-boosting medicinal mushroom compound. These researchers developed a patented fermentation process that substantially reduced the molecular weight (and therefore the size) of the polysaccharides in AHCC.

Normally, polysaccharides have a weight of 200,000 Daltons; the patented fermentation process used to create AHCC reduces their size to a mere 5,000 Daltons, leading to a dramatic increase in absorption and efficacy.


AHCC is obtained from the roots of several subspecies of hybridized medicinal mushrooms.

It is currently also the world’s most researched specialty immune supplement, supported by 20 human clinical studies, over 30 papers published in PubMed-indexed journals and by more than 100 pre-clinical and in vitro studies.  It has become Japan’s #1 immune supplement and has become increasingly popular in the United States.

As is typical of mushroom extracts, AHCC offers a significant boost to the immune system and has been shown to offer numerous health benefits, from improving the immune response of healthy people to the influenza vaccine and to stabilizing one man’s chronic lymphocytic leukemia (CLL).

Other ongoing research shows it may also be beneficial in treating or controlling:

  • HPV
  • Breast Cancer
  • Other types of cancer (particularly prostate, liver, lung, colon, pancreatic, stomach, brain, ovarian, etc.)
  • The negative side effects of chemotherapy
  • Liver ailments.
  • Diabetes
  • And more (for the full list, click here).

That’s because of how AHCC works.  AHCC works by turning up the dial on the body’s natural immune response and has been to shown to increase the number and activity of disease-fighting white blood cells so that the body can easily identify viruses, bacteria, and abnormal cells and fight back more effectively against illness. 


To date, as many as 150 species of mushroom have been identified as medicinal mushrooms. Popular species include button mushrooms, chaga, cordyceps, shiitake, maitake and reishi mushrooms, each of which demonstrate positive impacts on the immune system. Extracts or teas are then made from these mushrooms to help improve absorption.

Button Mushrooms — Button mushrooms contain significant amounts of copper, which  helps to create red blood cells. According to sources at LiveStrong, “One cup of cooked  button mushrooms supplies the body with 16% of the daily value of iron, important for  blood and energy, and 12% of the daily percentage of Vitamin C.”

Chaga Mushrooms — Chaga Mushrooms have demonstrated a wide range of beneficial  behaviors including—according to the Memorial Sloan-Kettering Cancer Center anticancer, antiviral, antiplatelet, anti-inflammatory, analgesic, immune stimulating  properties in vitro and hypoglycemic effects in mice.

 Cordyceps — Cordyceps is a fungi that has been used for a wide range of conditions.   In vitro and animal studies have shown it to have antitumor, radio-protective and anti- diabetic effects; it has also been used to treat fatigue, sexual dysfunction, coughs and  as an immune stimulant.

Shiitake — The Shiitake mushroom is cultivated worldwide for its purported health  benefits. Lentinan, a polysaccharide isolated from Shiitake, has been shown to have  anticancer effects in colon cancer cells. Lentin, the protein component, has strong  antifungal properties as well as other positive immune system effects, such as inhibiting  the proliferation of leukemic cells.

  Maitake — Maitake, the “dancing mushroom,” is used in traditional medicine to treat  diabetes and hypertension. Extracts are commonly marketed to enhance immune  function and to treat HIV and cancer.

  Reishi — Reishi mushrooms have been used for over 4,000 years for a variety of health  benefits, including longevity, disease resistance and energy and memory enhancements.  Additionally, they have been known to treat cancer, hepatitis, heart disease, arthritis,  prevent the death of lymphatic cells, lower blood pressure and increase daily energy   levels.

Related Blog Posts

View the Clinical Studies

Review AHCC research pertaining to a particular ailment.

Explore Studies

Interested to learn more?

Please beware of some products sold online claiming to be “generic versions” of AHCC®. These are considered “adulterated” by the FDA. Click here to see all the authentic verified AHCC® products from various nutritional supplement brands.