Pre Clinical and In Vitro Studies
Use this page as your direct resource and access point for all pre-clinical and in vitro studies done about AHCC®. Download the complete PDF or click to read a summary of each study.
In vivo research has shown that AHCC modulates the immune response against a variety of infectious agents, including influenza virus (the common flu), avian influenza virus (“bird flu”), Klebsiella pneumoniaebacteria (which causes pneumonia), Candida albicans fungus (which causes yeast infections), Pseudomonas aeruginosa bacteria (which can infect any part of the body), and methicillin-resistant Staphylococcus aureusbacteria (or MSRA, which causes an antibiotic-resistant staph infection). Most recently, AHCC was found to boost protective immune response specific to the West Nile Virus in mice.
Studies have repeatedly shown that mice treated with AHCC prior to infection with these pathogens experience:
- Decreased severity of infection
- Shortened recovery time
- Increased survival
In fact, one study found that mice pretreated with AHCC before infection with K. pneumoniae had completely cleared the bacteria from their systems by day 6, whereas control mice had increased levels of the bacteria and became extremely sick.
AHCC appears to have several benefits for diabetics. A small human clinical trial conducted in Japan found that all 13 diabetic patients enrolled in the study experienced a significant drop in blood glucose and glycohemoglobin levels after taking AHCC for six months. (Kenner, p. 21)
AHCC’s blood-sugar lowering effect was also observed in animal research. Diabetes was induced in rats through injection with the chemical streptozotocin (STZ). Among untreated (control) animals, blood glucose levels increased, insulin levels decreased, and insulin-secreting cells were damaged. Among AHCC-treated rats, however, blood glucose levels decreased, insulin levels increased, and there was little damage to insulin-secreting cells.
|Protective Effects of AHCC® on the onset of diabetes induced by Streptozotocin in the Rat||Dokkyo University School of Medicine|
AHCC AND INFLAMMATION
While many people associate inflammation with arthritis, few realize it is one of the underlying contributors to a number of different diseases, from asthma to heart disease to Alzheimer’s. In acute situations, such as sickness or injury, inflammation is helpful because it helps the body eliminate pathogens. When inflammation becomes chronic, however, it can destroy healthy tissue. Research shows that AHCC has a profound anti-inflammatory effect.
One study found that AHCC administration attenuated inflammation in rats with colitis (inflammation of the colon) at a level equal to that of the anti-inflammatory drug sulfasalazine. Another study observed that AHCC protected rats from the damaging effects of peritonitis (inflammation of the peritoneum, the membrane that lines the abdominal cavity). (Kenner, p. 23)
|Suppressive Efect of AHCC® on acute inflamation||Faculty of Pharmaceutical Sciences, Teiko University|
It is widely recognized that stress plays a major role in the etiology of many diseases. When people and animals are under stress, several things happen: The production of stress hormones such as adrenalin and corticosteroids increases, uric acid production increases, and blood sugar rise.
A study in rats that had been stressed through immobilization found that AHCC mediated the stress response, keeping levels of stress hormones, uric acid, and blood sugar normal.
Other in vivo studies have shown that as a potent antioxidant, AHCC may also protect against disorders caused by oxidative stress (cellular stress caused by free radicals).
|AHCC® on Immobilization Stress in the Rat||Department of Biochemistry, Dokkyo University School of Medicine|