Pre Clinical and In Vitro Studies

AHCC AND INFECTION

In vivo research has shown that AHCC modulates the immune response against a variety of infectious agents, including influenza virus (the common flu), avian influenza virus (“bird flu”), Klebsiella pneumoniaebacteria (which causes pneumonia), Candida albicans fungus (which causes yeast infections), Pseudomonas aeruginosa bacteria (which can infect any part of the body), and methicillin-resistant Staphylococcus aureusbacteria (or MSRA, which causes an antibiotic-resistant staph infection). Most recently, AHCC was found to boost protective immune response specific to the West Nile Virus in mice.

Studies have repeatedly shown that mice treated with AHCC prior to infection with these pathogens experience:

1. Decreased severity of infection
2. Shortened recovery time
3. Increased survival

In fact, one study found that mice pretreated with AHCC before infection with K. pneumoniae had completely cleared the bacteria from their systems by day 6, whereas control mice had increased levels of the bacteria and became extremely sick.

Topic	Publication	Downloads
AHCC® enhances resistance to Covid-19 infection	MDPI – Pathogens
Active Hexose Correlated Compound Enhanced the Immune Function of Mice in the Hindlimb-Unloading Model of Spaceflight Conditions	Journal of Applied Physiology
AHCC Activate Immune Function to Decrease Bacterial Load in Murine Model of Intramuscular Infection	The American Journal of Surgery
AHCC can Reduce the Severity of Influenza	The Journal of Nutrition, Nutritional Immunology
AHCC improves the antibody response to the influenza B vaccine	Department of Food Science and Human Nutrition, Michigan State University
AHCC Enhances Resistance to Infection in a Mouse Model of Surgical Wound Infection	Surgical Infections
AHCC Enhances Resistance to Klebsiella Pneumoniae Infection in Mice	Journal of Applied Physiology
AHCC Normalizes Immune Function	AHCC Research 9th Symposium
AHCC on Immobilization Stress in Rat: Beneficial Effects of AHCC	Dokkyo Journal of Medical Science
AHCC Protects the Thymus Gland	Endocrine Regulations
AHCC Significantly Raised the Survival Rate of Avian Flu	15th International Symposium of the AHCC Research Association
Independant Comparison of NK Activity in AHCC and MGN-3	Hokkaido University
Low-dose supplementation with active hexose correlated compoundimproves the immune response to acute influenza infection inC57BL/6 mice	Department of Biology Drexel University
Nutritional Food Active Hexose Correlated Compound AHCC Enhances Resistance Against Bird Flu	Japanese Journal of Complimentary and Alternative Medicine
Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to WestNile Encephalitis in Mice	Journal of Nutrition Science and Vitaminology
Role of AHCC in Helping to Build up Immunity	Japanese Journal of Complementary and Alternative Medicine
Supplementation with active hexose correlated compound increases survival following infectious challenge in mice	Emerging Science
Supplementation with Active Hexose Correlated Compound Increases the Innate Immune response of young mice to Primary Influenza Infection	Journal of Nutrition

AHCC appears to have several benefits for diabetics. A small human clinical trial conducted in Japan found that all 13 diabetic patients enrolled in the study experienced a significant drop in blood glucose and glycohemoglobin levels after taking AHCC for six months. (Kenner, p. 21)

AHCC’s blood-sugar lowering effect was also observed in animal research. Diabetes was induced in rats through injection with the chemical streptozotocin (STZ). Among untreated (control) animals, blood glucose levels increased, insulin levels decreased, and insulin-secreting cells were damaged. Among AHCC-treated rats, however, blood glucose levels decreased, insulin levels increased, and there was little damage to insulin-secreting cells.

Topic	Publication	Downloads
Protective Effects of AHCC® on the onset of diabetes induced by Streptozotocin in the Rat	Dokkyo University School of Medicine

AHCC AND INFLAMMATION

While many people associate inflammation with arthritis, few realize it is one of the underlying contributors to a number of different diseases, from asthma to heart disease to Alzheimer’s. In acute situations, such as sickness or injury, inflammation is helpful because it helps the body eliminate pathogens. When inflammation becomes chronic, however, it can destroy healthy tissue. Research shows that AHCC has a profound anti-inflammatory effect.

One study found that AHCC administration attenuated inflammation in rats with colitis (inflammation of the colon) at a level equal to that of the anti-inflammatory drug sulfasalazine. Another study observed that AHCC protected rats from the damaging effects of peritonitis (inflammation of the peritoneum, the membrane that lines the abdominal cavity). (Kenner, p. 23)

Topic	Publication	Downloads
Suppressive Efect of AHCC® on acute inflamation	Faculty of Pharmaceutical Sciences, Teiko University

It is widely recognized that stress plays a major role in the etiology of many diseases. When people and animals are under stress, several things happen: The production of stress hormones such as adrenalin and corticosteroids increases, uric acid production increases, and blood sugar rise.

A study in rats that had been stressed through immobilization found that AHCC mediated the stress response, keeping levels of stress hormones, uric acid, and blood sugar normal.

Other in vivo studies have shown that as a potent antioxidant, AHCC may also protect against disorders caused by oxidative stress (cellular stress caused by free radicals).

Topic	Publication	Downloads
AHCC® on Immobilization Stress in the Rat	Department of Biochemistry, Dokkyo University School of Medicine