Human Clinical Studies

Learn more about AHCC® with direct access to the clinical studies completed about AHCC® and its effectiveness. Choose to download the complete PDF or click to read a summary of each study.
AHCC® is the world’s most researched specialty immune supplement, supported by over 30 human studies and by more than 100 pre-clinical in vivo and in vitro studies. It is utilized by over 1,000 healthcare facilities worldwide to reduce the incidence of infections in both healthy and immune-compromised patients, improve cancer patient outcomes, decrease chemo side-effects, help control HPV infections, manage viral loads in Hepatitis-C patients and help those with liver disease. To review research pertaining to a particular ailment, select the condition from the grid below.

Studies

Overview

AHCC has been used with great success in cancer patients. Data from the treatment of over 100,000 individuals with various types of cancer have shown AHCC treatment to be of benefit in 60% of cases. (Kenner p. 15) AHCC is particularly effective for liver, lung, stomach, colon, breast, thyroid, ovarian, testicular, tongue, kidney and pancreatic cancers. (Kenner p. 15)
One landmark AHCC trial enrolled 269 patients with liver cancer. Following surgery, about half of the patients took AHCC and about half did not. The results were dramatic: At the end of the ten-year study, only 34.5% of the AHCC patients experienced a recurrence in their cancer, compared with 66.1% of the control group. Similarly, while 46.8% of the patients in the control group had died at the end of ten years, less than half that amount — 20.4% — of those in the AHCC group had. Another study found that AHCC not only prolonged survival of advanced liver cancer patients, it also improved various parameters of quality of life, including mental stability, general physical health status and the ability to have normal activities.

Title of Article Publication Downloads Summary
AHCC® Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer Frontiers in Immunology Read More
Can AHCC be used in the treatment of head and neck cancer patients? International Journal of Clinical Medicine, 2, 588-592 (2011)
Can AHCC improve the prognosis of hepatocellular carcinoma (HCC) patients following surgical treatment? Journal of Hepatology
Does AHCC have an effect on castration-resistant prostate cancer (CRPC)? Anti-Cancer Drugs 2009, 20: 215-216
Does AHCC have an effect on patients with advanced breast cancer? International Journal of Integrative Oncology
Does AHCC have an effect on patients with advanced liver cancer? Asian Pacific Journal of Allergy and Immunology
Does AHCC have an effect on patients with early stage prostate cancer? Japanese Journal of Clinical Oncology.
Does AHCC have an effect on patients with pancreatic or biliary tract cancer who underwent chemotherapy? Presented at the 40th APA (American Pancreatic Association)
Does AHCC have an effect on the survival rate of patients with gastric cancer or colon cancer? Natural Medicine Journal.
Does AHCC have immunomodulatory and anticancer effects in cancer patients? International Journal of Immunotherapy
Does AHCC in combination with GCP extend survival and quality of life in stage IV lung and breast cancer patients? 16th AHCC Research Association, November 2008
What have been some clinical experiences with AHCC and cancer? Biotherapy 2000; 14(10): 959-964
Which out of four dietary supplements commonly sold in health food stores can consistently and statistically affect NK cell activity in cancer patients? Townsend Letter for Doctors and Patients February/March 2003
Overview

Chemotherapy is fraught with side effects, which range from psychologically distressing to life-threatening. In addition to being able to fight cancer directly, AHCC also alleviates many of the side effects of chemotherapy, including:

  • Hair Loss: Doctors noticed that chemotherapy patients taking AHCC did not lose their hair. Subsequently, an in vivo study found that mice treated with AHCC were protected from chemically induced hair loss.
  • Nausea: Clinical studies in Korea and Japan have indicated that AHCC remarkably improves symptoms of nausea and vomiting in cancer patients. (Kenner, p. 18)
  • Bone Marrow Suppression: Chemotherapy can inhibit bone marrow function, which is life-threatening because the body’s key immune soldiers — the white blood cells — originate in bone marrow. AHCC has been shown to raise the white blood cell count of cancer patients by about 30%. (Kenner, p. 17)
  • Liver Damage: One of the major drawbacks of chemotherapy is that it kills healthy cells in addition to cancer cells. An in vivo study found that while rats given chemotherapy experienced large increases in liver enzymes (indicative of liver damage), those given chemotherapy plus AHCC had normal levels. (Kenner, p. 17)
Title of Article Publication Downloads Summary
Does AHCC alleviate the adverse events in the adjuvant chemotherapy of breast cancer patients? Presented at the 20th International Congress on Nutrition and Integrative Medicine
Does AHCC have a biological response modifier (BRM)-like effect in advanced-stage cancer patients? Biotherapy
Does AHCC have a hematoimmunologic effect on cancer patients? Biotherapy
Does AHCC have an immunomodulating effect on cancer patients? Presented at 2nd Meeting of the Society for Natural Immunity, May 1994
Is AHCC safe and can AHCC reduce the chemotherapy-induced adverse effects in cancer patients? Presented at the 17th AHCC Research Association, 2009
What effect does AHCC have on the reduction of adverse effects in advanced cancer patients on chemotherapy with weakened immune systems experiencing HHV-6 herpes virus infection and liver and blood toxicity? Nutrition and Cancer
What is the difference in chemotherapy treatment adverse effects and incidence in those receiving AHCC and those who didn’t? The Journal of Alternative and Complementary Medicine
Overview

Dr. Fred Pescatore, of the Center for Integrative and Complementary Medicine in New York, has reported that he has achieved marked reductions in the liver enzymes of hepatitis patients through the use of AHCC. This is an important discovery, as high levels of liver enzymes are indicative of liver damage. Dr. Pescatore has also observed massive drops in the viral loads of hepatitis C patients. One case study, a 47 year-old male, had a viral load of 2,498,200 before treatment, which plunged to 499,600 after six months on AHCC — an 80% reduction.
Animal studies confirm AHCC’s liver-protective effect. Rats treated with AHCC and then administered the liver-toxic chemical carbon tetrachloride were spared from its liver-damaging effect. Similarly, rats treated with AHCC and then administered the lethal substance galactosamine had an improved survival rate compared to control rats. (Kenner, p. 19).

Title of Article Publication Downloads Summary
Can AHCC improve liver function in patients with non-viral, chronic and abnormal liver function conditions? Presented at the 18th International Congress on Nutrition and Integrative Medicine (ICNIM), July 2010
Does AHCC have an effect on patients with chronic hepatitis C? Medical News (Thailand)
What is the effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation? Journal of Nutrition Science Vitaminology

Title of Article Publication Downloads Summary
Does AHCC have an effect on immune function of healthy adults aged 50 or greater? Human Immunology
Does AHCC have an effect on immune response of healthy adults after influenza vaccinations? Nutrition Research
Does AHCC have an effect on immune responses in healthy volunteers? Nutrition and Cancer

Title of Article Publication Downloads Summary
Can women with HPV-positive Pap tests who don’t show signs of abnormal cytology (abnormal cervical cells) and are treated with active hexose correlated compound (AHCC) undergo clearance of the infection? 11th International Conference of the Society for Integrative Oncology
Is AHCC safe and tolerable in healthy subjects? Journal of Nutrition Science and Vitaminology
What effect does active hexose correlated compound (AHCC) supplementation have in patients diagnosed with pharmacoresistant epilepsy, to what degree is there a role in the immune system disease pathogenesis, and what is the efficacy of immune therapy? 22nd International Congress on Nutrition and Integrative Medicine
What is the effect of active hexose correlated compound (AHCC) on immune competence in human subjects? Journal of Evidence-Based Complementary & Alternative Medicine
Title of Article Publication Downloads Summary
Can AHCC be used in the treatment of head and neck cancer patients? International Journal of Clinical Medicine, 2, 588-592 (2011)
Can AHCC improve the prognosis of hepatocellular carcinoma (HCC) patients following surgical treatment? Journal of Hepatology
Does AHCC have an effect on castration-resistant prostate cancer (CRPC)? Anti-Cancer Drugs 2009, 20: 215-216
Does AHCC have an effect on patients with advanced breast cancer? International Journal of Integrative Oncology
Does AHCC have an effect on patients with advanced liver cancer? Asian Pacific Journal of Allergy and Immunology
Does AHCC have an effect on patients with early stage prostate cancer? Japanese Journal of Clinical Oncology.
Does AHCC have an effect on patients with pancreatic or biliary tract cancer who underwent chemotherapy? Presented at the 40th APA (American Pancreatic Association)
Does AHCC have an effect on the survival rate of patients with gastric cancer or colon cancer? Natural Medicine Journal.
Does AHCC have immunomodulatory and anticancer effects in cancer patients? International Journal of Immunotherapy
Does AHCC in combination with GCP extend survival and quality of life in stage IV lung and breast cancer patients? 16th AHCC Research Association, November 2008
What have been some clinical experiences with AHCC and cancer? Biotherapy 2000; 14(10): 959-964
Which out of four dietary supplements commonly sold in health food stores can consistently and statistically affect NK cell activity in cancer patients? Townsend Letter for Doctors and Patients February/March 2003
Does AHCC alleviate the adverse events in the adjuvant chemotherapy of breast cancer patients? Presented at the 20th International Congress on Nutrition and Integrative Medicine
Does AHCC have a biological response modifier (BRM)-like effect in advanced-stage cancer patients? Biotherapy
Does AHCC have a hematoimmunologic effect on cancer patients? Biotherapy
Does AHCC have an immunomodulating effect on cancer patients? Presented at 2nd Meeting of the Society for Natural Immunity, May 1994
Is AHCC safe and can AHCC reduce the chemotherapy-induced adverse effects in cancer patients? Presented at the 17th AHCC Research Association, 2009
What effect does AHCC have on the reduction of adverse effects in advanced cancer patients on chemotherapy with weakened immune systems experiencing HHV-6 herpes virus infection and liver and blood toxicity? Nutrition and Cancer
What is the difference in chemotherapy treatment adverse effects and incidence in those receiving AHCC and those who didn’t? The Journal of Alternative and Complementary Medicine
Can AHCC improve liver function in patients with non-viral, chronic and abnormal liver function conditions? Presented at the 18th International Congress on Nutrition and Integrative Medicine (ICNIM), July 2010
Does AHCC have an effect on patients with chronic hepatitis C? Medical News (Thailand)
What is the effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation? Journal of Nutrition Science Vitaminology
Does AHCC have an effect on immune function of healthy adults aged 50 or greater? Human Immunology
Does AHCC have an effect on immune response of healthy adults after influenza vaccinations? Nutrition Research
Does AHCC have an effect on immune responses in healthy volunteers? Nutrition and Cancer
Can women with HPV-positive Pap tests who don’t show signs of abnormal cytology (abnormal cervical cells) and are treated with active hexose correlated compound (AHCC) undergo clearance of the infection? 11th International Conference of the Society for Integrative Oncology
Is AHCC safe and tolerable in healthy subjects? Journal of Nutrition Science and Vitaminology
What effect does active hexose correlated compound (AHCC) supplementation have in patients diagnosed with pharmacoresistant epilepsy, to what degree is there a role in the immune system disease pathogenesis, and what is the efficacy of immune therapy? 22nd International Congress on Nutrition and Integrative Medicine
What is the effect of active hexose correlated compound (AHCC) on immune competence in human subjects? Journal of Evidence-Based Complementary & Alternative Medicine

Books

ABC Book

Description

B and T cells: Both B cells (which mature in bone marrow) and T cells (which mature in the thymus) are lymphocytes, WBC that are able to recognize previous invaders and destroy them with a specific response

Please beware of some products sold online claiming to be “generic versions” of AHCC®. These are considered “adulterated” by the FDA. Click here to see all the authentic verified AHCC® products from various nutritional supplement brands.

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