Studies

AHCC® Association is dedicated to providing the latest information on AHCC® mushroom extract to ensure consumers understand what AHCC® is, how it works, news articles, and studies on its clinically-proven efficacy in addressing a wide range of ailments.

Clinical Studies by Condition

Overview

AHCC has been used with great success in cancer patients. Data from the treatment of over 100,000 individuals with various types of cancer have shown AHCC treatment to be of benefit in 60% of cases. (Kenner p. 15)
AHCC is particularly effective for liver, lung, stomach, colon, breast, thyroid, ovarian, testicular, tongue, kidney and pancreatic cancers. (Kenner p. 15) One landmark AHCC trial enrolled 269 patients with liver cancer. Following surgery, about half of the patients took AHCC and about half did not. The results were dramatic: At the end of the ten-year study, only 34.5% of the AHCC patients experienced a recurrence in their cancer, compared with 66.1% of the control group. Similarly, while 46.8% of the patients in the control group had died at the end of ten years, less than half that amount — 20.4% — of those in the AHCC group had. Another study found that AHCC not only prolonged survival of advanced liver cancer patients, it also improved various parameters of quality of life, including mental stability, general physical health status and the ability to have normal activities.

Read More​

Published Human Studies

AHCC® Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer

Frontiers in Immunology

Can AHCC be used in the treatment of head and neck cancer patients?

International Journal of Clinical Medicine, 2, 588-592 (2011)

Can AHCC improve the prognosis of hepatocellular carcinoma (HCC) patients following surgical treatment?

Journal of Hepatology

Does AHCC have an effect on castration-resistant prostate cancer (CRPC)?

Anti-Cancer Drugs 2009, 20: 215-216

Does AHCC have an effect on patients with advanced breast cancer?

International Journal of Integrative Oncology

Does AHCC have an effect on patients with advanced liver cancer?

Asian Pacific Journal of Allergy and Immunology

Does AHCC have an effect on patients with early stage prostate cancer?

Japanese Journal of Clinical Oncology

Does AHCC have an effect on patients with pancreatic or biliary tract cancer who underwent chemotherapy?

Presented at the 40th APA (American Pancreatic Association)

Does AHCC have an effect on the survival rate of patients with gastric cancer or colon cancer?

Natural Medicine Journal

Does AHCC have immunomodulatory and anticancer effects in cancer patients?

International Journal of Immunotherapy

Does AHCC in combination with GCP extend survival and quality of life in stage IV lung and breast cancer patients?

16th AHCC Research Association, November 2008

What have been some clinical experiences with AHCC and cancer?

Biotherapy 2000; 14(10): 959-964

Which out of four dietary supplements commonly sold in health food stores can consistently and statistically affect NK cell activity in cancer patients?

Townsend Letter for Doctors and Patients February/March 2003

Overview

Herpes viruses are a family of viral infections that remain dormant in the body and can reactivate periodically. Unlike many other viruses, herpesviruses include multiple types that can cause a range of health issues.
The most common types affecting humans are Herpes Simplex Virus type 1 (HSV-1), which typically causes oral herpes, and Herpes Simplex Virus type 2 (HSV-2), which usually causes genital herpes. Other members of the herpesvirus family include Epstein-Barr Virus (EBV, also known as Human Herpesvirus 4), associated with mononucleosis and certain cancers, and Human Herpesvirus 6 (HHV-6), linked to roseola and some neurological conditions. As we have seen with other infection-based AHCC studies, research studies suggest that AHCC supplementation may support the immune system’s fight against herpesvirus infections. Preliminary evidence and research on immune modulation indicate that AHCC may help the body suppress viral activity, which could reduce the frequency or severity of outbreaks. Additionally, by enhancing immune function, AHCC supplementation may support the body’s ability to keep herpesvirus infections in their dormant state and lower the risk of virus-related complications.

Read More

Published Human Studies

Significance of the Levels of Human Herpes virus 6 in Saliva as a Biomarker in the Reduction of Adverse Effects by AHCC

“Nutrition and Cancer” journal

Experience of the Clinical Use of AHCC® in the Treatment of Severe Forms of Herpes Virus Infections

Dermatovenereology and Gynecology (Almaty, Kazakhstan)

AHCC Induces Production of IL-12 and Interferon -α & γ in Cells from Subjects with Recurring Herpes Simplex Type 1&2 Infections

National Academy of Medical Science of Ukraine (Kiev, Ukraine)

Epstein Barr Herpes virus 4: miRNA and its influence on immune system and risk factors: Diagnostics and Clinical Outcome of a Study

Prevention and Regeneration Clinic (Munich, Germany)

Overview

Human Papillomavirus (HPV) is a viral infection. Unlike most other viruses, HPV has high-risk strains that are known to cause cancers.
As we have seen with other infection-based AHCC studies, clinical results suggest that AHCC supplementation supports the immune system’s fight against Human Papillomavirus (HPV) infections. In the majority of cases, AHCC cleared existing HPV infections making the virus undetectable. Additionally, the use of AHCC supplementation may help prevent HPV-associated cancers from developing if the body successfully clears the initial infection.
Read More

Published Human Studies​

AHCC Supports Immune Function to Clear Persistent HPV Infections

Frontiers in Oncology

Evaluation of AHCC in Modulating Host Immunity to Clear High-Risk HPV Infections

Frontiers in Oncology

Overview

Chemotherapy is fraught with side effects, which range from psychologically distressing to life-threatening.

In addition to being able to fight cancer directly, AHCC also alleviates many of the side effects of chemotherapy, including:
  • Hair Loss: Doctors noticed that chemotherapy patients taking AHCC did not lose their hair. Subsequently, an in vivo study found that mice treated with AHCC were protected from chemically induced hair loss.
  • Nausea: Clinical studies in Korea and Japan have indicated that AHCC remarkably improves symptoms of nausea and vomiting in cancer patients. (Kenner, p. 18)
  • Bone Marrow Suppression: Chemotherapy can inhibit bone marrow function, which is life-threatening because the body’s key immune soldiers — the white blood cells — originate in bone marrow. AHCC has been shown to raise the white blood cell count of cancer patients by about 30%. (Kenner, p. 17)
  • Liver Damage: One of the major drawbacks of chemotherapy is that it kills healthy cells in addition to cancer cells. An in vivo study found that while rats given chemotherapy experienced large increases in liver enzymes (indicative of liver damage), those given chemotherapy plus AHCC had normal levels. (Kenner, p. 17)

Read More

Published Human Studies​

AHCC® Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer

Frontiers in Immunology

Can AHCC be used in the treatment of head and neck cancer patients?

International Journal of Clinical Medicine, 2, 588-592 (2011)

Can AHCC improve the prognosis of hepatocellular carcinoma (HCC) patients following surgical treatment?

Journal of Hepatology

Does AHCC have an effect on castration-resistant prostate cancer (CRPC)?

Anti-Cancer Drugs 2009, 20: 215-216

Does AHCC have an effect on patients with advanced breast cancer?

International Journal of Integrative Oncology

Does AHCC have an effect on patients with advanced liver cancer?

Asian Pacific Journal of Allergy and Immunology

Does AHCC have an effect on patients with early stage prostate cancer?

Japanese Journal of Clinical Oncology

Does AHCC have an effect on patients with pancreatic or biliary tract cancer who underwent chemotherapy?

Presented at the 40th APA (American Pancreatic Association)

Does AHCC have an effect on the survival rate of patients with gastric cancer or colon cancer?

Natural Medicine Journal

Does AHCC have immunomodulatory and anticancer effects in cancer patients?

International Journal of Immunotherapy

Does AHCC in combination with GCP extend survival and quality of life in stage IV lung and breast cancer patients?

16th AHCC Research Association, November 2008

What have been some clinical experiences with AHCC and cancer?

Biotherapy 2000; 14(10): 959-964

Which out of four dietary supplements commonly sold in health food stores can consistently and statistically affect NK cell activity in cancer patients?

Townsend Letter for Doctors and Patients February/March 2003

Overview

Dr. Fred Pescatore, of the Center for Integrative and Complementary Medicine in New York, has reported that he has achieved marked reductions in the liver enzymes of hepatitis patients through the use of AHCC.
This is an important discovery, as high levels of liver enzymes are indicative of liver damage. Dr. Pescatore has also observed massive drops in the viral loads of hepatitis C patients. One case study, a 47 year-old male, had a viral load of 2,498,200 before treatment, which plunged to 499,600 after six months on AHCC — an 80% reduction. Animal studies confirm AHCC’s liver-protective effect. Rats treated with AHCC and then administered the liver-toxic chemical carbon tetrachloride were spared from its liver-damaging effect. Similarly, rats treated with AHCC and then administered the lethal substance galactosamine had an improved survival rate compared to control rats. (Kenner, p. 19).
Read More

Published Human Studies​

Can AHCC improve liver function in patients with non-viral, chronic and abnormal liver function conditions?

Presented at the 18th International Congress on Nutrition and Integrative Medicine (ICNIM), July 2010

Does AHCC have an effect on patients with chronic hepatitis C?

Medical News (Thailand)

What is the effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation?

Journal of Nutrition Science Vitaminology

Overview

Dr. Fred Pescatore, of the Center for Integrative and Complementary Medicine in New York, has reported that he has achieved marked reductions in the liver enzymes of hepatitis patients through the use of AHCC.
This is an important discovery, as high levels of liver enzymes are indicative of liver damage. Dr. Pescatore has also observed massive drops in the viral loads of hepatitis C patients. One case study, a 47 year-old male, had a viral load of 2,498,200 before treatment, which plunged to 499,600 after six months on AHCC — an 80% reduction. Animal studies confirm AHCC’s liver-protective effect. Rats treated with AHCC and then administered the liver-toxic chemical carbon tetrachloride were spared from its liver-damaging effect. Similarly, rats treated with AHCC and then administered the lethal substance galactosamine had an improved survival rate compared to control rats. (Kenner, p. 19).
Read More

Published Human Studies​

Does AHCC have an effect on immune function of healthy adults aged 50 or greater?

Human Immunology

Does AHCC have an effect on immune response of healthy adults after influenza vaccinations?

Nutrition Research

Does AHCC have an effect on immune responses in healthy volunteers?

Nutrition and Cancer

Overview

There have been numerous studies on AHCC’s effect on the immune system. Is it safe for adults with healthy immune systems? Is it safe to use for immunocompromised individuals? Can AHCC be used as immunotherapy? The following studies address these questions and more when it comes to AHCC’s impact on our immune systems.

Published Human Studies​

Is AHCC safe and tolerable in healthy subjects?

Journal of Nutrition Science and Vitaminology

What effect does active hexose correlated compound (AHCC) supplementation have in patients diagnosed with pharmacoresistant epilepsy, to what degree is there a role in the immune system disease pathogenesis, and what is the efficacy of immune therapy?

22nd International Congress on Nutrition and Integrative Medicine

What is the effect of active hexose correlated compound (AHCC) on immune competence in human subjects?

Journal of Evidence-Based Complementary & Alternative Medicine

Effect of (AHCC) on Fat Mass of Mice

Department of Pharmacology, Teiko University

All Published Research

CANCER

AHCC® Promotes the Anti-Tumor Effect of Dual Immune Checkpoint Blockade Effect in Murine Colon Cancer

Frontiers in Immunology

Can AHCC be used in the treatment of head and neck cancer patients?

International Journal of Clinical Medicine, 2, 588-592 (2011)

Can AHCC improve the prognosis of hepatocellular carcinoma (HCC) patients following surgical treatment?

Journal of Hepatology

Does AHCC have an effect on castration-resistant prostate cancer (CRPC)?

Anti-Cancer Drugs 2009, 20: 215-216

Does AHCC have an effect on patients with advanced breast cancer?

International Journal of Integrative Oncology

Does AHCC have an effect on patients with advanced liver cancer?

Asian Pacific Journal of Allergy and Immunology

Does AHCC have an effect on patients with early stage prostate cancer?

Japanese Journal of Clinical Oncology

Does AHCC have an effect on patients with pancreatic or biliary tract cancer who underwent chemotherapy?

Presented at the 40th APA (American Pancreatic Association)

Does AHCC have an effect on the survival rate of patients with gastric cancer or colon cancer?

Natural Medicine Journal

Does AHCC have immunomodulatory and anticancer effects in cancer patients?

International Journal of Immunotherapy

Does AHCC in combination with GCP extend survival and quality of life in stage IV lung and breast cancer patients?

16th AHCC Research Association, November 2008

What have been some clinical experiences with AHCC and cancer?

Biotherapy 2000; 14(10): 959-964

Which out of four dietary supplements commonly sold in health food stores can consistently and statistically affect NK cell activity in cancer patients?

Townsend Letter for Doctors and Patients February/March 2003

HERPES

Significance of the Levels of Human Herpes virus 6 in Saliva as a Biomarker in the Reduction of Adverse Effects by AHCC

“Nutrition and Cancer” journal

Experience of the Clinical Use of AHCC® in the Treatment of Severe Forms of Herpes Virus Infections

Dermatovenereology and Gynecology (Almaty, Kazakhstan)

AHCC Induces Production of IL-12 and Interferon -α & γ in Cells from Subjects with Recurring Herpes Simplex Type 1&2 Infections

National Academy of Medical Science of Ukraine (Kiev, Ukraine)

Epstein Barr Herpes virus 4: miRNA and its influence on immune system and risk factors: Diagnostics and Clinical Outcome of a Study

Prevention and Regeneration Clinic (Munich, Germany)

HPV

AHCC Supports Immune Function to Clear Persistent HPV Infections

Frontiers in Oncology

Evaluation of AHCC in Modulating Host Immunity to Clear High-Risk HPV Infections

Frontiers in Oncology

CHEMO SIDE-EFFECTS

Does AHCC alleviate the adverse events in the adjuvant chemotherapy of breast cancer patients?

Presented at the 20th International Congress on Nutrition and Integrative Medicine

Does AHCC have a biological response modifier (BRM)-like effect in advanced-stage cancer patients?

Biotherapy

Does AHCC have a hematoimmunologic effect on cancer patients?

Biotherapy

Is AHCC safe and can AHCC reduce the chemotherapy-induced adverse effects in cancer patients?

Presented at the 17th AHCC Research Association, 2009

Is AHCC safe and can AHCC reduce the chemotherapy-induced adverse effects in cancer patients?

Presented at the 17th AHCC Research Association, 2009

What effect does AHCC have on the reduction of adverse effects in advanced cancer patients on chemotherapy with weakened immune systems experiencing HHV-6 herpes virus infection and liver and blood toxicity?

Nutrition and Cancer

What is the difference in chemotherapy treatment adverse effects and incidence in those receiving AHCC and those who didn’t?

The Journal of Alternative and Complementary Medicine

LIVER

Can AHCC improve liver function in patients with non-viral, chronic and abnormal liver function conditions?

Presented at the 18th International Congress on Nutrition and Integrative Medicine (ICNIM), July 2010

Does AHCC have an effect on patients with chronic hepatitis C?

Medical News (Thailand)

What is the effect of Active Hexose Correlated Compound (AHCC) in alcohol-induced liver enzyme elevation?

Journal of Nutrition Science Vitaminology

HEALTHY ADULTS

Does AHCC have an effect on immune function of healthy adults aged 50 or greater?

Human Immunology

Does AHCC have an effect on immune response of healthy adults after influenza vaccinations?

Nutrition Research

Does AHCC have an effect on immune responses in healthy volunteers?

Nutrition and Cancer

IMMUNITY

Is AHCC safe and tolerable in healthy subjects?

Journal of Nutrition Science and Vitaminology

What effect does active hexose correlated compound (AHCC) supplementation have in patients diagnosed with pharmacoresistant epilepsy, to what degree is there a role in the immune system disease pathogenesis, and what is the efficacy of immune therapy?

22nd International Congress on Nutrition and Integrative Medicine

What is the effect of active hexose correlated compound (AHCC) on immune competence in human subjects?

Journal of Evidence-Based Complementary & Alternative Medicine

Effect of (AHCC) on Fat Mass of Mice

Department of Pharmacology, Teiko University

Published Research

Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses

Cancer Immunology Immunother

AHCC®‘s Beneficial Immuno Modulation Effects in the Thymus

Endocrine Regulations

Anti-Tumor Effects of Genistein Combined Polysaccharide (GCP) and Active Hexose Correlated Compound (AHCC®)

Biotherapy 2001; 15(3):379-382

Application of New Immunotherapy Using AHCC® for Animal Disease

Presentation

Augmentation of canine cellular immune response by administration of AHCC®

Presentation

Combination therapy of Active Hexose Correlated Compound AHCC® on Thymic Apoptosis Induced by Dexometasone in the Rat

Endocrine Regulations 2006

Combination therapy of Active Hexose Correlated Compound AHCC® plus UFT significantly Reduces The metastasis of Rat Mamary Adenocarcinoma

Anti-Cancer Drugs

Evaluation of Active Hexose Correlated Compound for the Prevention or Delay of Tumor Growth in Human Cervical Cancer Xenograft Model

Cancer Prevention Research

H-2 Haplotype-Dependent Serum IL-12 in Tumor-Bearing Mice Treated with Various Mycelial Extracts

Study Abstract

Published Research

Ameliorative Effect of AHCC for Anticancer Drug Induced Side Effects

Amino up Chemical CO., LTD

Evaluation of Active Hexose Correlated Compound AHCC Hepatic Metabolism and Potential for Drug Interactions with Chemotherapy Agents

Journal of Social Integral Oncology

The Influence of AHCC on Cisplatin-Evoked Chemotherapeutic and Side Effects in Tumor-Bearing Mice

Toxicology and Applied Pharmacology

Published Research

AHCC Protects the Liver

Natural Medicine

Effect of AHCC on the Production of Nitric Oxide in Hepatocytes

Journal of Parenteral and Enteral Nutrition

Supressive Effects of AHCC on the Increased Activity of Hepatic and Renal Ornithine Decarboxylase Induced by Oxidative Stress

Life Sciences

Overview

In vivo research has shown that AHCC modulates the immune response against a variety of infectious agents, including influenza virus (the common flu), avian influenza virus (“bird flu”), Klebsiella pneumoniaebacteria (which causes pneumonia), Candida albicans fungus (which causes yeast infections), Pseudomonas aeruginosa bacteria (which can infect any part of the body), and methicillin-resistant Staphylococcus aureusbacteria (or MSRA, which causes an antibiotic-resistant staph infection).
Most recently, AHCC was found to boost protective immune response specific to the West Nile Virus in mice. Studies have repeatedly shown that mice treated with AHCC prior to infection with these pathogens experience:
  • Decreased severity of infection
  • Shortened recovery time
  • Increased survival
In fact, one study found that mice pretreated with AHCC before infection with K. pneumoniae had completely cleared the bacteria from their systems by day 6, whereas control mice had increased levels of the bacteria and became extremely sick.
Read More​

Published Research

AHCC® enhances resistance to Covid-19 infection

The Journal of Nutrition, Nutritional Immunology

Active Hexose Correlated Compound Enhanced the Immune Function of Mice in the Hindlimb-Unloading Model of Spaceflight Conditions

Journal of Applied Physiology

AHCC Activate Immune Function to Decrease Bacterial Load in Murine Model of Intramuscular Infectio

The American Journal of Surgery

AHCC can Reduce the Severity of Influenza

The Journal of Nutrition, Nutritional Immunology

AHCC improves the antibody response to the influenza B vaccine

Department of Food Science and Human Nutrition, Michigan State University

AHCC Enhances Resistance to Infection in a Mouse Model of Surgical Wound Infection

Surgical Infections

AHCC Enhances Resistance to Klebsiella Pneumoniae Infection in Mice

Journal of Applied Physiology

AHCC Normalizes Immune Function

AHCC Research 9th Symposium

AHCC on Immobilization Stress in Rat: Beneficial Effects of AHCC

Dokkyo Journal of Medical Science

AHCC Protects the Thymus Gland

Endocrine Regulations

AHCC Significantly Raised the Survival Rate of Avian Flu

15th International Symposium of the AHCC Research Association

Independant Comparison of NK Activity in AHCC and MGN-3

Hokkaido University

Low-dose supplementation with active hexose correlated compoundimproves the immune response to acute influenza infection inC57BL/6 mice

Department of Biology Drexel University

Nutritional Food Active Hexose Correlated Compound AHCC Enhances Resistance Against Bird Flu

Japanese Journal of Complimentary and Alternative Medicine

Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to WestNile Encephalitis in Mice

Journal of Nutrition Science and Vitaminology

Role of AHCC in Helping to Build up Immunity

Japanese Journal of Complementary and Alternative Medicine

Supplementation with active hexose correlated compound increases survival following infectious challenge in mice

Emerging Science

Supplementation with Active Hexose Correlated Compound Increases the Innate Immune response of young mice to Primary Influenza Infection

Journal of Nutrition

Overview

AHCC appears to have several benefits for diabetics. A small human clinical trial conducted in Japan found that all 13 diabetic patients enrolled in the study experienced a significant drop in blood glucose and glycohemoglobin levels after taking AHCC for six months. (Kenner, p. 21)

AHCC’s blood-sugar lowering effect was also observed in animal research. Diabetes was induced in rats through injection with the chemical streptozotocin (STZ). Among untreated (control) animals, blood glucose levels increased, insulin levels decreased, and insulin-secreting cells were damaged. Among AHCC-treated rats, however, blood glucose levels decreased, insulin levels increased, and there was little damage to insulin-secreting cells.

Published Research

Protective Effects of AHCC® on the onset of diabetes induced by Streptozotocin in the Rat

Dokkyo University School of Medicine

Overview

While many people associate inflammation with arthritis, few realize it is one of the underlying contributors to a number of different diseases, from asthma to heart disease to Alzheimer’s. In acute situations, such as sickness or injury, inflammation is helpful because it helps the body eliminate pathogens. When inflammation becomes chronic, however, it can destroy healthy tissue. Research shows that AHCC has a profound anti-inflammatory effect.

One study found that AHCC administration attenuated inflammation in rats with colitis (inflammation of the colon) at a level equal to that of the anti-inflammatory drug sulfasalazine. Another study observed that AHCC protected rats from the damaging effects of peritonitis (inflammation of the peritoneum, the membrane that lines the abdominal cavity). (Kenner, p. 23)

Published Research

Suppressive Efect of AHCC® on acute inflamation

Faculty of Pharmaceutical Sciences, Teiko University

Overview

It is widely recognized that stress plays a major role in the etiology of many diseases. When people and animals are under stress, several things happen: The production of stress hormones such as adrenalin and corticosteroids increases, uric acid production increases, and blood sugar rise.

A study in rats that had been stressed through immobilization found that AHCC mediated the stress response, keeping levels of stress hormones, uric acid, and blood sugar normal.

Other in vivo studies have shown that as a potent antioxidant, AHCC may also protect against disorders caused by oxidative stress (cellular stress caused by free radicals).

Published Research

AHCC® on Immobilization Stress in the Rat

Department of Biochemistry, Dokkyo University School of Medicine

All Published Research

CANCER

Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses

Cancer Immunology Immunother

AHCC®‘s Beneficial Immuno Modulation Effects in the Thymus

Endocrine Regulations

Anti-Tumor Effects of Genistein Combined Polysaccharide (GCP) and Active Hexose Correlated Compound (AHCC®)

Biotherapy 2001; 15(3):379-382

Application of New Immunotherapy Using AHCC® for Animal Disease

Presentation

Augmentation of canine cellular immune response by administration of AHCC®

Presentation

Combination therapy of Active Hexose Correlated Compound AHCC® on Thymic Apoptosis Induced by Dexometasone in the Rat

Endocrine Regulations 2006

Combination therapy of Active Hexose Correlated Compound AHCC® plus UFT significantly Reduces The metastasis of Rat Mamary Adenocarcinoma

Anti-Cancer Drugs

Evaluation of Active Hexose Correlated Compound for the Prevention or Delay of Tumor Growth in Human Cervical Cancer Xenograft Model

Cancer Prevention Research

H-2 Haplotype-Dependent Serum IL-12 in Tumor-Bearing Mice Treated with Various Mycelial Extracts

Study Abstract

CHEMO

Ameliorative Effect of AHCC for Anticancer Drug Induced Side Effects

Amino up Chemical CO., LTD

Evaluation of Active Hexose Correlated Compound AHCC Hepatic Metabolism and Potential for Drug Interactions with Chemotherapy Agents

Journal of Social Integral Oncology

The Influence of AHCC on Cisplatin-Evoked Chemotherapeutic and Side Effects in Tumor-Bearing Mice

Toxicology and Applied Pharmacology

LIVER

AHCC Protects the Liver

Natural Medicine

Effect of AHCC on the Production of Nitric Oxide in Hepatocytes

Journal of Parenteral and Enteral Nutrition

Supressive Effects of AHCC on the Increased Activity of Hepatic and Renal Ornithine Decarboxylase Induced by Oxidative Stress

Life Sciences

INFECTION

AHCC® enhances resistance to Covid-19 infection

The Journal of Nutrition, Nutritional Immunology

Active Hexose Correlated Compound Enhanced the Immune Function of Mice in the Hindlimb-Unloading Model of Spaceflight Conditions

Journal of Applied Physiology

AHCC Activate Immune Function to Decrease Bacterial Load in Murine Model of Intramuscular Infectio

The American Journal of Surgery

AHCC can Reduce the Severity of Influenza

The Journal of Nutrition, Nutritional Immunology

AHCC improves the antibody response to the influenza B vaccine

Department of Food Science and Human Nutrition, Michigan State University

AHCC Enhances Resistance to Infection in a Mouse Model of Surgical Wound Infection

Surgical Infections

AHCC Enhances Resistance to Klebsiella Pneumoniae Infection in Mice

Journal of Applied Physiology

AHCC Normalizes Immune Function

AHCC Research 9th Symposium

AHCC on Immobilization Stress in Rat: Beneficial Effects of AHCC

Dokkyo Journal of Medical Science

AHCC Protects the Thymus Gland

Endocrine Regulations

AHCC Significantly Raised the Survival Rate of Avian Flu

15th International Symposium of the AHCC Research Association

Independant Comparison of NK Activity in AHCC and MGN-3

Hokkaido University

Low-dose supplementation with active hexose correlated compoundimproves the immune response to acute influenza infection inC57BL/6 mice

Department of Biology Drexel University

Nutritional Food Active Hexose Correlated Compound AHCC Enhances Resistance Against Bird Flu

Japanese Journal of Complimentary and Alternative Medicine

Oral Administration of Active Hexose Correlated Compound Enhances Host Resistance to WestNile Encephalitis in Mice

Journal of Nutrition Science and Vitaminology

Role of AHCC in Helping to Build up Immunity

Japanese Journal of Complementary and Alternative Medicine

Supplementation with active hexose correlated compound increases survival following infectious challenge in mice

Emerging Science

Supplementation with Active Hexose Correlated Compound Increases the Innate Immune response of young mice to Primary Influenza Infection

Journal of Nutrition

DIABETES

Protective Effects of AHCC® on the onset of diabetes induced by Streptozotocin in the Rat

Dokkyo University School of Medicine

INFLAMATION

Suppressive Efect of AHCC® on acute inflamation

Faculty of Pharmaceutical Sciences, Teiko University

STRESS

AHCC® on Immobilization Stress in the Rat

Department of Biochemistry, Dokkyo University School of Medicine

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